The Management of Antiphospholipid Antibodies Affected Pregnancy
نویسندگان
چکیده
Antiphospholipid antibody (aPL) is a heterogeneous group of autoantibodies directed against phospholipids-binding proteins. Antiphospholipid syndrome (APS) is defined by two major components: 1) presence of at least one type of aPLs, 2) the occurrence of at least one clinical feature from a list of potential disease manifestations, the most common of which are categorized as venous or arterial thromboses, and pregnancy complications. The pregnancy complications include recurrent spontaneous abortion (RSA), unexplained fetal death, severe pre-eclampsia, fetal growth restriction (FGR), and premature delivery. International consensus conferences have proposed and revised classification criteria for definite APS. Two types of aPLs were originally included in the laboratory criteria: IgG and IgM anticardiolipin antibody (aCL); and lupus anticoagulant (LA) (1). After that, IgG and IgM anti-β2 glycoprotein-I antibody (aβ2GPI) were included as laboratory criteria (2). However, scant evidence exists in regard to a relationship between the aPL profile and serious adverse pregnancy outcome.
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نشانگان آنتی فسفولیپید
Antiphospholipid syndrome is an autoimmune condition characterized by recurrent vascular thrombosis, pregnancy loss and thrombocytopenia associated with moderate to high levels of antiphospholipid antibodies. Most of clinical features are results of thrombotic phenomena. The pathophysiologic basis ot this syndrome is still unknown. the diagnosis of this syndrome is made by combination of clinic...
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